Department of Cardiovascular, Respiratory and Metabolic Medicine, Kagoshima University, Japan.
J Atheroscler Thromb. 2009;16(6):840-5. doi: 10.5551/jat.1230. Epub 2009 Dec 22.
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease, although it has yet to be established whether CKD is an independent risk factor for arterial stiffness in community residents. The purpose of this study was to determine the correlation between the cardio-ankle vascular index (CAVI) and estimated glomerular filtration rate (eGFR) in the general population.
We studied 881 consecutively enrolled subjects undergoing health checkups. CAVI was calculated automatically from the pulse volume record, blood pressure and the vascular length from the heart to the ankle. CKD was evaluated by the eGFR.
The distribution of eGFR was as follows: 241 with eGFR (mL/min/1.73m(2)) > or =90; 572 with eGFR 60-89; 65 with eGFR 30-59; 3 with eGFR 15-29; 0 with eGFR <15. Linear regression analysis showed that CAVI was negatively correlated significantly with eGFR, while multiple regression analysis using CAVI as an objective variable, adjusted for conventional atherosclerotic risk factors and eGFR as explanatory variables, demonstrated that CAVI was an independent determinant of eGFR. We also showed that stepwise increments of CAVI occurred with progressive deterioration of CKD.
CAVI was independently correlated with eGFR indicating that CKD is associated with arterial stiffness in the general population.
慢性肾脏病（CKD）与心血管疾病风险增加相关，但尚未确定 CKD 是否是社区居民动脉僵硬的独立危险因素。本研究旨在确定一般人群中心血管脚踝血管指数（CAVI）与估算肾小球滤过率（eGFR）之间的相关性。
我们研究了 881 名连续接受健康检查的受试者。CAVI 自动从脉搏容积记录、血压和从心脏到脚踝的血管长度计算得出。通过 eGFR 评估 CKD。
eGFR 的分布如下：241 例 eGFR（mL/min/1.73m²）≥90；572 例 eGFR 为 60-89；65 例 eGFR 为 30-59；3 例 eGFR 为 15-29；0 例 eGFR <15。线性回归分析表明，CAVI 与 eGFR 呈显著负相关，而使用 CAVI 作为因变量、调整传统动脉粥样硬化危险因素和 eGFR 作为解释变量的多元回归分析表明，CAVI 是 eGFR 的独立决定因素。我们还表明，随着 CKD 的逐渐恶化，CAVI 逐渐增加。
CAVI 与 eGFR 独立相关，表明 CKD 与一般人群的动脉僵硬有关。
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