Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Hospital Healthcare System Gangnam Center.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital Healthcare System Gangnam Center.
J Atheroscler Thromb. 2022 Dec 1;29(12):1774-1790. doi: 10.5551/jat.63371. Epub 2022 Mar 31.
We investigated the effects of metabolic syndrome (MetS) and its components, including a body shape index (ABSI), on increased arterial stiffness measured using the cardio-ankle vascular index (CAVI) according to sex and age strata.
A total of 7127 asymptomatic Korean participants aged 21-90 years (men, 69.4%) were included. Age-sex-specific increased CAVI was defined as having the highest quartile of CAVI in each age group.
The CAVI increased with age and was higher in men. MetS was associated with an increased risk of high CAVI by 1.30 times in men and 1.45 times in women. The risk of high CAVI with an increasing MetS risk score was greater in women. MetS was significantly associated with increased CAVI in men only aged 51-70 years and in women aged ≥ 51 years, and the size of association increased with age (odds ratio (OR) of 1.41 in 51-70 years vs. OR of 2.96 in ≥ 71 years of women). Among MetS components, triglyceride (men, all ages), hypertension (men, 51-70 years; women, ≤ 70 years), glucose intolerance (men, 51-70 years; women, ≥ 51 years), and HDL-cholesterol (women, ≥ 71 years) were associated with increased CAVI.Unlike increased waist circumference (WC), increased ABSI revealed an association with high CAVI. MetS diagnosed with ABSI instead of WC was more significantly associated with increased CAVI in all age-sex groups.
The association of MetS and its components with increased CAVI differed with age and sex, which might provide a new insight for the management of MetS risk factors to promote vascular health.
本研究旨在探讨代谢综合征（MetS）及其组分，包括体脂指数（ABSI），对根据性别和年龄分层的心血管踝血管指数（CAVI）测量的动脉僵硬度增加的影响。
共纳入 7127 名无症状韩国参与者（男性占 69.4%），年龄 21-90 岁。年龄和性别特异性的 CAVI 升高定义为每个年龄组中 CAVI 的最高四分位数。
CAVI 随年龄增长而增加，男性更高。男性 MetS 与 CAVI 升高风险增加 1.30 倍，女性增加 1.45 倍。女性的 MetS 风险评分越高，发生 CAVI 升高的风险越大。仅在 51-70 岁的男性和≥51 岁的女性中，MetS 与 CAVI 增加显著相关，且随着年龄的增长，关联度增大（51-70 岁男性的比值比为 1.41，≥71 岁女性的比值比为 2.96）。在 MetS 组分中，甘油三酯（男性，所有年龄）、高血压（男性，51-70 岁；女性，≤70 岁）、葡萄糖耐量异常（男性，51-70 岁；女性，≥51 岁）和高密度脂蛋白胆固醇（女性，≥71 岁）与 CAVI 增加相关。与腰围增加不同，ABSI 增加与 CAVI 升高相关。用 ABSI 诊断的 MetS 与用 WC 诊断的 MetS 相比，与所有年龄和性别组的 CAVI 增加相关性更显著。
MetS 及其组分与 CAVI 增加的相关性因年龄和性别而异，这可能为管理 MetS 危险因素以促进血管健康提供新的视角。
