Horie S, Fukumori N, Suga T
Department of Clinical Biochemistry, Tokyo College of Pharmacy, Japan.
Toxicol Lett. 1991 Mar;55(3):249-54. doi: 10.1016/0378-4274(91)90004-p.
The acute effect of an antimycotic drug, bifonazole, on hepatic peroxisomes of rats was studied in comparison with that of clotrimazole, which has a similar structure. By feeding 0.5% bifonazole in the diet for 5 days, the activities of carnitine acyltransferase, carnitine palmitoyltransferase and the peroxisomal beta-oxidation system were increased by 30-, 3- and 7-fold, respectively, over the control. Under the same conditions, clotrimazole did not cause such changes. Electron microscopic observation showed that peroxisome proliferation had been induced by bifonazole treatment. Thus, a compound which does not contain a carboxylate moiety can induce peroxisomes in rodent liver.
研究了抗真菌药物联苯苄唑对大鼠肝脏过氧化物酶体的急性作用，并与结构相似的克霉唑进行了比较。通过在饮食中添加0.5%的联苯苄唑持续5天，肉碱酰基转移酶、肉碱棕榈酰转移酶和过氧化物酶体β-氧化系统的活性分别比对照组增加了30倍、3倍和7倍。在相同条件下，克霉唑未引起此类变化。电子显微镜观察表明，联苯苄唑处理可诱导过氧化物酶体增殖。因此，一种不含羧酸盐部分的化合物可诱导啮齿动物肝脏中的过氧化物酶体。
