Ishii H, Horie S, Suga T
J Biochem. 1980 Jun;87(6):1855-8. doi: 10.1093/oxfordjournals.jbchem.a132931.
In the livers of fasted rats, the activity of peroxisomal palmitocyl-CoA oxidation (NADH production) was increased more rapidly and markedly than that of mitochondrial carnitine palmitoyltransferase, which is the rate limiting enzyme of mitochondrial beta-oxidation. The peroxisomal oxidizing activity was about twice that of the control throughout the period of fasting (1-7 days). carnitine acetyltransferase activity was increased to a similar extent in both peroxisomes and mitochondria. A possible physiological role of liver peroxisomes may thus be as an effective supply of NADH2, acetyl residues and short and medium-length fatty acyl-CoA in the cells on the enhancement of peroxisomal beta-oxidation of the animals under starvation; these substances thus produced may be transported into the mitochondria as energy sources.
在禁食大鼠的肝脏中，过氧化物酶体棕榈酰辅酶A氧化（产生NADH）的活性比线粒体肉碱棕榈酰转移酶的活性增加得更快且更显著，线粒体肉碱棕榈酰转移酶是线粒体β氧化的限速酶。在整个禁食期（1 - 7天），过氧化物酶体氧化活性约为对照组的两倍。肉碱乙酰转移酶活性在过氧化物酶体和线粒体中均有类似程度的增加。因此，肝脏过氧化物酶体的一个可能生理作用可能是在饥饿状态下增强动物过氧化物酶体β氧化时，为细胞有效提供NADH₂、乙酰基以及短链和中链脂肪酰辅酶A；由此产生的这些物质可作为能量来源转运到线粒体中。
