Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives.
作者信息
Karadsheh N, Kussie P, Linthicum D S
机构信息
Department of Veterinary Microbiology and Parasitology, College of Veterinary Medicine, Texas A&M University, College Station 77843-4467.
出版信息
Toxicol Lett. 1991 Mar;55(3):335-42. doi: 10.1016/0378-4274(91)90015-x.
PMID:2003276
Abstract
The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined. Most of the compounds had moderate inhibitory activity with I50 values in the range of 87-480 microM. The inhibition of AChE by these compounds has not been previously reported. A structural feature common to these compounds is the N-methyl determinant of the pyrrolidine ring which may be important in binding to the AChE.
摘要
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