Tsougos Ioannis, Loudos George, Georgoulias Panagiotis, Theodorou Kiki, Kappas Constantin
Department of Medical Physics, Medical School, University of Thessaly, University Hospital, Larissa, Greece.
Nucl Med Commun. 2010 Feb;31(2):97-106. doi: 10.1097/MNM.0b013e328330626f.
The development of patient-specific treatment planning systems is of outmost importance in the development of radionuclide dosimetry, taking into account that quantitative three-dimensional nuclear medical imaging can be used in this regard. At present, the established method for dosimetry is based on the measurement of the biokinetics by serial gamma-camera scans, followed by calculations of the administered activity and the residence times, resulting in the radiation-absorbed doses of critical organs. However, the quantification of the activity in different organs from planar data is hampered by inaccurate attenuation and scatter correction as well as because of background and organ overlay. In contrast, dosimetry based on quantitative three-dimensional data can be more accurate and allows an individualized approach, provided that all effects that degrade the quantitative content of the images have been corrected for. In addition, inhomogeneous organ accumulation of the radionuclide can be detected and possibly taken into account. The aim of this work is to provide adequate information on internal emitter dosimetry and a state-of-the-art review of the current methodology and future trends.
考虑到定量三维核医学成像可用于此，患者特异性治疗计划系统的开发在放射性核素剂量测定的发展中至关重要。目前，既定的剂量测定方法基于通过串行γ相机扫描测量生物动力学，随后计算给药活度和停留时间，从而得出关键器官的辐射吸收剂量。然而，平面数据中不同器官活度的量化受到不准确的衰减和散射校正以及背景和器官重叠的阻碍。相比之下，基于定量三维数据的剂量测定可以更准确，并允许采用个体化方法，前提是已对所有降低图像定量内容的影响进行了校正。此外，可以检测到放射性核素在器官中的不均匀积聚，并可能加以考虑。这项工作的目的是提供有关体内发射体剂量测定的充分信息，并对当前方法和未来趋势进行最新综述。
