循环微颗粒可能影响颈动脉早期重塑。

Circulating microparticles may influence early carotid artery remodeling.

机构信息

AP-HP, Hôpital Européen Georges Pompidou, Service de Cardiologie Préventive, Paris, France.

出版信息

J Hypertens. 2010 Apr;28(4):789-96. doi: 10.1097/HJH.0b013e328335d0a8.

DOI:10.1097/HJH.0b013e328335d0a8

PMID:20032788

Abstract

OBJECTIVES

To test associations of circulating microparticles with large artery remodeling before atherosclerosis is detectable.

METHODS

In 232 untreated symptom-free individuals, we measured microparticles of various cellular origins (platelet, endothelial and leukocyte) by specific anti-GPIb (glycoprotein Ib), anti-cluster of differentiation (CD) 105 and anti-CD11a antibodies, and common carotid artery intima-media thickness (IMT), internal and external diameters by ultrasound.

RESULTS

Except for CD105 microparticles with IMT to lumen ratio (IMT/D, P < 0.05), microparticles correlated with no carotid dimensions. Significant interactions existed between each microparticle type and IMT on internal and external diameters (GPIb, P < 0.01; CD105 and CD11a microparticles P < 0.001) consisting of lower trend in increased diameter with increasing IMT in individuals with high than in those with low microparticle level (according to the median) of each origin. As a result, individuals within the third IMT tertile had lower internal diameter in the presence of high than in the presence of low level of GPIb, CD105 or CD11a microparticles (P = 0.001, <0.05 or 0.01, respectively), and lower external diameter in the presence of high than in the presence of low level of GPIb and CD11a microparticles (P = 0.001 and 0.01). Also, individuals within third IMT tertile exhibited positive correlations of IMT with CD105 and CD11a microparticles (P < 0.05), negative correlations of internal diameter with GPIb (P < 0.05), CD105 (P < 0.05) and CD11a microparticles (P < 0.01) and of external diameter with GPIb and CD11a microparticles (P < 0.05), and positive correlations of IMT/D with CD105 and CD11a microparticles (P < 0.001).

CONCLUSION

Increased levels of leukocyte and endothelial-derived microparticles are associated with carotid inward remodeling in individuals with the greatest IMT before atherosclerosis is detectable.

摘要

目的

在可检测动脉粥样硬化之前，检测循环微粒与大动脉重塑的关联。

方法

在 232 名未经治疗无症状的个体中，我们通过特异性抗糖蛋白 Ib（GPIb）、抗分化群（CD）105 和抗 CD11a 抗体测量了各种细胞来源的微粒（血小板、内皮和白细胞），并通过超声测量颈总动脉内膜-中层厚度（IMT）、内-外径。

结果

除了与 IMT 与管腔比（IMT/D）相关的 CD105 微粒（P < 0.05）外，微粒与颈动脉各维度均不相关。每种微粒类型与 IMT 之间存在显著的相互作用，包括内-外径（GPIb，P < 0.01；CD105 和 CD11a 微粒，P < 0.001），在高微粒水平的个体中，直径随 IMT 增加而呈下降趋势，而在低微粒水平的个体中则呈上升趋势（根据中位数）。因此，在第 3 个 IMT 三分位数内，高微粒水平的个体中存在低内-径，而在高微粒水平的个体中存在低内-径（P = 0.001，<0.05 或 0.01），并且在高微粒水平的个体中存在低外-径（P = 0.001 和 0.01）。此外，第 3 个 IMT 三分位数内的个体中 IMT 与 CD105 和 CD11a 微粒呈正相关（P < 0.05），内-径与 GPIb（P < 0.05）、CD105（P < 0.05）和 CD11a 微粒（P < 0.01）呈负相关，外-径与 GPIb 和 CD11a 微粒（P < 0.05）呈负相关，而 IMT/D 与 CD105 和 CD11a 微粒呈正相关（P < 0.001）。