Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Int J Mol Sci. 2021 Apr 15;22(8):4108. doi: 10.3390/ijms22084108.
Lifestyle changes, such as overeating and underexercising, can increase the risk of prediabetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addition to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.
生活方式的改变，如暴饮暴食和运动不足，会增加前驱糖尿病的风险。糖尿病是动脉粥样硬化的主要原因之一，最近人们清楚地认识到，动脉粥样硬化的病理生理学甚至在糖尿病症状出现之前就已经进展。除了高血糖状态下血小板和白细胞的变化以及血管内皮细胞的损伤外，还发现细胞外囊泡和 microRNAs 参与了前驱糖尿病动脉粥样硬化的进展。本文综述了这些过程的细胞和分子机制，旨在使人们全面了解前驱糖尿病和动脉粥样硬化的病理生理学。
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