Department of Pediatrics, Institute of Pharmacology, Charité, Berlin, Germany.
Pharmacogenet Genomics. 2010 Feb;20(2):139-42. doi: 10.1097/FPC.0b013e3283357337.
It was suggested that fetal sex may substantially affect maternal glycemic control during pregnancy in genetically susceptible mothers. The peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is known to affect glycemic control and may act in a sex-specific manner. This polymorphism is thus an attractive candidate to test this hypothesis using a second independent functionally relevant polymorphism. We analyzed the impact of fetal sex on maternal glycemic control during pregnancy in relation to the maternal PPARgamma2 Pro12Ala polymorphism. Two-thousand fourteen Caucasian women without preexisting diabetes and preexisting hypertension with singleton pregnancies delivering consecutively at the Charité obstetrics department were genotyped. Glycemic control was analyzed by measuring total glycated hemoglobin at birth. Correction for confounding factors and multiple testing was considered in the analysis. The maternal PPARgamma2 Pro12Ala polymorphism without consideration of fetal sex had no effect on blood pressure, new onset of proteinuria and total glycated hemoglobin at delivery. Mothers carrying both G alleles (GG genotype) delivering a girl had a higher (P = 0.015) total glycated hemoglobin (6.81 or - 0.50%) versus mothers carrying the same alleles but delivering boys (5.85 + or - 0.58%). Comparing mothers with the GG genotype delivering girls with mothers with CC or CG genotypes also delivering girls (6.32 + or - 0.72%) revealed a significantly higher maternal total glycated hemoglobin at delivery in the former group (P < 0.009). Fetal sex/sex chromosomes may substantially affect maternal glycemic control in mothers who are carriers of the GG alleles of the PPARgamma2 Pro12Ala polymorphism.
有人提出，在具有遗传易感性的母亲中，胎儿性别可能会极大地影响妊娠期间的母体血糖控制。过氧化物酶体增殖物激活受体γ2（PPARγ2）Pro12Ala 多态性已知会影响血糖控制，并且可能具有性别特异性作用。因此，该多态性是使用第二个独立的功能相关多态性来检验该假设的有吸引力的候选者。我们分析了胎儿性别对具有 PPARγ2 Pro12Ala 多态性的母亲妊娠期间母体血糖控制的影响。对连续在 Charité 妇产科分娩的没有糖尿病前期和高血压前期的 2114 名白种人女性进行了基因分型。通过出生时测量总糖化血红蛋白来分析血糖控制。在分析中考虑了混杂因素和多次检验的校正。不考虑胎儿性别的母体 PPARγ2 Pro12Ala 多态性对血压、新发生的蛋白尿和分娩时的总糖化血红蛋白没有影响。携带两个 G 等位基因（GG 基因型）并分娩女孩的母亲的总糖化血红蛋白（6.81 或-0.50%）高于携带相同等位基因但分娩男孩的母亲（5.85 +-0.58%）。与携带 GG 基因型并分娩女孩的母亲相比，与携带 CC 或 CG 基因型的母亲相比，携带 GG 基因型并分娩女孩的母亲的总糖化血红蛋白也更高（6.32 +-0.72%）（P<0.009）。在携带 PPARγ2 Pro12Ala 多态性 GG 等位基因的母亲中，胎儿性别/性染色体可能会极大地影响母体血糖控制。
