Division of Nephrology, University of Virginia, Charlottesville, Virginia 22908-0133, USA.
Kidney Int. 2010 Mar;77(5):393-9. doi: 10.1038/ki.2009.489. Epub 2009 Dec 23.
A newly described glomerulotubular feedback loop may explain the relationship between glomerular damage, epitope spreading, tubulointerstitial nephritis, proteinuria as a progression factor, and the importance of the local milieu in kidney damage. It also opens the horizons for exciting innovative approaches to therapy of both acute and chronic kidney diseases.
一个新描述的肾小球小管反馈环路可能解释了肾小球损伤、抗原表位扩展、肾小管间质性肾炎、蛋白尿作为进展因素之间的关系,以及局部环境在肾脏损伤中的重要性。它也为急性和慢性肾脏疾病的治疗提供了令人兴奋的创新方法的前景。