Tianjin Neurological Institute, Neurology, Tianjin Medical University General Hospital, Tianjin, China.
Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
J Cereb Blood Flow Metab. 2020 Feb;40(2):246-262. doi: 10.1177/0271678X19890931. Epub 2019 Nov 25.
Stroke is a leading cause of mortality and morbidity, with long-term debilitating effects. Accumulating evidence from experimental studies as well as observational studies in patients suggests a cross talk between the brain and kidney after stroke. Stroke may lead to kidney dysfunction which can adversely impact patient outcome. In this review article, we discuss the epidemiology and mechanisms of brain–kidney interaction following ischemic stroke. Specifically, we discuss the role of the central autonomic network, autoregulation, inflammatory and immune responses, the role of extracellular vesicles and their cargo microRNA, in mediating brain–kidney interaction following stroke. Understanding the bidirectional nature of interaction between the brain and kidney after cerebral injury would have clinical implications for the treatment of stroke and overall patient outcome.
中风是死亡和发病的主要原因，具有长期致残的影响。来自实验研究和患者观察研究的累积证据表明，中风后大脑和肾脏之间存在交叉对话。中风可能导致肾功能障碍，从而对患者的预后产生不利影响。在这篇综述文章中，我们讨论了缺血性中风后大脑-肾脏相互作用的流行病学和机制。具体来说，我们讨论了中枢自主神经系统、自动调节、炎症和免疫反应、细胞外囊泡及其携带的 microRNA 在介导中风后大脑-肾脏相互作用中的作用。了解脑损伤后大脑和肾脏之间相互作用的双向性质，将对中风的治疗和整体患者预后具有临床意义。
