Department of Dermatology, Academic Medical Center, Amsterdam, The Netherlands.
J Invest Dermatol. 2010 May;130(5):1318-22. doi: 10.1038/jid.2009.404. Epub 2009 Dec 24.
In dermatology, the clinical use of health-related quality of life (HRQL) scores is impeded by lack of empirically and clinically based interpretation of these scores. We aimed to facilitate the interpretation of Skindex-29 domain and overall scores by identifying clinically meaningful cut-off scores, using patient-based anchors. Consecutively included dermatology outpatients completed the Skindex-29 and four sets of anchor-based questions, such as questions on the impact of skin disease on HRQL, on global disease severity, and on psychiatric morbidity. Pearson's correlations and receiver operating characteristic analysis were used to identify the optimal Skindex-29 cut-off scores corresponding to severely impaired HRQL. A total of 339/434 patients completed the questionnaires (response rate 78%), of which 322 could be used for data analysis. Cut-off scores associated with the patient-based anchors on the impact of skin disease on HRQL showed the highest accuracy (area under the curve ranged from 0.83 to 0.91). The corresponding Skindex-29 cut-off scores for severely impaired HRQL were as follows: > or =52 points on symptoms, > or =39 on emotions, > or =37 on functioning, and > or =44 on the overall score. The estimated cut-off scores can be used in clinical practice to identify patients with (very) severely impaired HRQL.
在皮肤病学中，由于缺乏对这些分数的经验和临床基础的解释，健康相关生活质量（HRQL）评分的临床应用受到阻碍。我们旨在通过确定基于患者的切点来促进 Skindex-29 领域和整体评分的解释，这些切点基于经验和临床。连续纳入皮肤科门诊患者完成 Skindex-29 和四组基于锚的问题，例如关于皮肤病对 HRQL、全球疾病严重程度和精神疾病发病率的影响的问题。使用 Pearson 相关分析和接收者操作特性分析来确定与严重受损 HRQL 相对应的最佳 Skindex-29 切点分数。共有 339/434 名患者完成了问卷（应答率 78%），其中 322 名可用于数据分析。与基于患者的皮肤病对 HRQL 影响的锚点相关的切点分数显示出最高的准确性（曲线下面积范围为 0.83 至 0.91）。严重受损 HRQL 的相应 Skindex-29 切点分数如下：症状>或=52 分，情绪>或=39 分，功能>或=37 分，总体评分>或=44 分。估计的切点分数可用于临床实践中，以识别（非常）严重受损 HRQL 的患者。
