Pathak R, Gabor A J
Department of Neurology, University of California, Davis, Sacramento.
Stroke. 1991 Mar;22(3):410-3. doi: 10.1161/01.str.22.3.410.
We describe a patient with scleroderma (CREST syndrome) and central nervous system vasculitis. While angiography demonstrated segmental symmetrical arterial narrowing characteristic of vasculitis, results of leptomeningeal biopsy were normal. There was no evidence of systemic vasculitis, renal failure, or malignant hypertension previously thought to be required to explain central nervous system dysfunction in patients with scleroderma. Signs and symptoms attributable to vasculitis were reversible with aggressive immunosuppressive therapy.
我们描述了一名患有硬皮病（CREST综合征）和中枢神经系统血管炎的患者。血管造影显示出血管炎典型的节段性对称动脉狭窄，而软脑膜活检结果正常。没有证据表明存在先前认为解释硬皮病患者中枢神经系统功能障碍所需的系统性血管炎、肾衰竭或恶性高血压。血管炎所致的体征和症状通过积极的免疫抑制治疗可逆转。
