Department of Pediatrics, Division of Immunology-Rheumatology, Dokuz Eylül University Hospital, Balcova-Izmir, Turkey.
Clin Rheumatol. 2010 Apr;29(4):375-9. doi: 10.1007/s10067-009-1330-9. Epub 2009 Dec 22.
Familial Mediterranean fever (FMF) is the most common autoinflammatory disease which requires a lifelong treatment. The aim of this study was to evaluate the depression and anxiety in pediatric FMF patients. The Children's Depression Inventory and the Screen for Child Anxiety-related Emotional Disorders were the instruments used. Forty-three patients with FMF and 53 healthy controls were compared. Both study and control groups were divided into two age groups, 7-12 and 13-18 years. The depression scores of patients with FMF were significantly higher than their healthy peers (p = 0.001). However, there was no significant difference between patients with FMF and control group regarding the anxiety scores (p = 0.78). The disease duration was not significantly correlated with depression and anxiety scores. There was a significant correlation between depression score and FMF severity score (p = 0.01). The mean depression and anxiety scores of the FMF patients were positively correlated with the number of attacks (p = 0.000 and p = 0.001, respectively).This study suggested that patients with FMF were considerably more depressed than their healthy peers and that the depression scores were negatively affected from disease severity score and number of attacks. Psychosocial assessment of children with FMF has potential clinical implications and individualized counseling and interventions are needed.
家族性地中海热（FMF）是最常见的自身炎症性疾病，需要终身治疗。本研究旨在评估儿科 FMF 患者的抑郁和焦虑。使用了儿童抑郁量表和儿童焦虑相关情绪障碍筛查表。将 43 名 FMF 患者和 53 名健康对照者进行比较。研究组和对照组均分为 7-12 岁和 13-18 岁两个年龄组。FMF 患者的抑郁评分明显高于健康同龄人（p=0.001）。然而，FMF 患者与对照组之间的焦虑评分无显著差异（p=0.78）。疾病持续时间与抑郁和焦虑评分无显著相关性。抑郁评分与 FMF 严重程度评分呈显著相关（p=0.01）。FMF 患者的平均抑郁和焦虑评分与发作次数呈正相关（p=0.000 和 p=0.001）。本研究表明，FMF 患者明显比健康同龄人抑郁，抑郁评分受疾病严重程度评分和发作次数的负面影响。对 FMF 患儿进行心理社会评估具有潜在的临床意义，需要进行个体化咨询和干预。
