Kucuksahin Orhan, Omma Ahmet, Ozdemirel Ali Erhan, Tecer Duygu, Ulutas Sümeyye, Maras Yüksel, Balkarlı Ayşe, Erten Şükran
Department of Rheumatology, Medical Faculty, Yıldırım Beyazit University, Ankara, Turkey.
Rheumatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Int J Rheum Dis. 2018 Oct;21(10):1849-1856. doi: 10.1111/1756-185X.13104. Epub 2017 May 31.
To evaluate the sleep quality and the relation of sleep quality with depression, anxiety, fatigue and disease activity in adult patients with familial Mediterranean fever (FMF).
One hundred and seventy-four FMF patients and 84 age-sex matched healthy individuals were included in this study. The Pittsburgh Sleep Quality Index (PSQI), Multidimensional Assessment of Fatigue (MAF) and the Hospital Anxiety and Depression Index (HADS) were used to assess sleep quality, fatigue, depression and anxiety, respectively.
FMF patients had significantly higher depression, anxiety, fatigue and PSQI scores than healthy controls. As the severity of the disease increased, scores of total PSQI and its domains increased. Patients with total PSQI score higher than 5 had statistically significantly higher erythrocyte sedimentation rates (ESR), serum C-reactive protein and serum amyloid levels during attacks, more attack numbers in last 3 months and worse fatigue, depression scores. Total PSQI score was positively correlated with inflammatory markers during attacks, attack numbers in the last 3 months and fatigue score. Logistic regression models identified disease duration, ESR during attacks, fatigue, attack numbers in the last 3 months as predictors of poor sleep quality.
Poor sleep quality is common in adult FMF patients. Anxiety, depression and fatigue are more frequent in FMF patients than healthy individuals. Poor sleep quality is associated with inflammatory marker levels during attacks, fatigue and attack numbers in the last 3 months.
评估成年家族性地中海热（FMF）患者的睡眠质量，以及睡眠质量与抑郁、焦虑、疲劳和疾病活动之间的关系。
本研究纳入了174例FMF患者和84例年龄及性别匹配的健康个体。分别使用匹兹堡睡眠质量指数（PSQI）、疲劳多维评估量表（MAF）和医院焦虑抑郁量表（HADS）来评估睡眠质量、疲劳、抑郁和焦虑。
FMF患者的抑郁、焦虑、疲劳和PSQI评分显著高于健康对照组。随着疾病严重程度的增加，PSQI总分及其各维度得分均升高。PSQI总分高于5分的患者在发作期间红细胞沉降率（ESR）、血清C反应蛋白和血清淀粉样蛋白水平在统计学上显著更高，过去3个月内发作次数更多，疲劳和抑郁评分更差。PSQI总分与发作期间的炎症标志物、过去3个月内的发作次数以及疲劳评分呈正相关。逻辑回归模型确定疾病持续时间、发作期间的ESR、疲劳、过去3个月内的发作次数是睡眠质量差的预测因素。
成年FMF患者睡眠质量差很常见。FMF患者比健康个体更容易出现焦虑、抑郁和疲劳。睡眠质量差与发作期间的炎症标志物水平、疲劳以及过去3个月内的发作次数有关。
