MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Behav Genet. 2010 May;40(3):415-23. doi: 10.1007/s10519-009-9323-7. Epub 2009 Dec 22.
We attempt to identify gene by childhood abuse interactions which predispose to the development of schizotypal traits in a familial bipolar disorder (BD) sample. Self-report measures of schizotypal personality traits (Schizotypal Personality Scale) and childhood maltreatment (Childhood Trauma Questionnaire) were administered to 222 participants from 44 families with BD. Variants of catechol-o-methyltransferase (COMT) and four other dopamine pathway-related genes: DRD4, DRD2,MAOA, and SLC6A3, were typed. BD type I (BD I) subjects scored significantly higher than their unaffected relatives on the Schizotypal Personality Scale. The val allele of the Val158 Met polymorphism of the COMT gene was associated with increased schizotypal personality trait scores in individuals exposed to higher levels of self-reported childhood trauma (p < 0.05). There was no direct effect of the val158met polymorphism on schizotypal personality traits. Further, no passive correlation between COMT genotype and childhood trauma was found. We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits.
我们试图在一个有家族性双相情感障碍（BD）的样本中识别与儿童期虐待相互作用的基因，这些基因易导致分裂型特质的发展。对来自 44 个 BD 家庭的 222 名参与者进行了分裂型人格特质（分裂型人格量表）和儿童期虐待（儿童期创伤问卷）的自评测量。对儿茶酚-O-甲基转移酶（COMT）和其他四种多巴胺途径相关基因（DRD4、DRD2、MAOA 和 SLC6A3）的变体进行了分型。BD I 型（BD I）患者在分裂型人格量表上的得分明显高于未受影响的亲属。COMT 基因 Val158 Met 多态性的 val 等位基因与报告的较高水平的儿童期创伤个体的分裂型人格特质得分增加相关（p < 0.05）。COMT val158met 多态性对分裂型人格特质没有直接影响。此外，没有发现 COMT 基因型与儿童期创伤之间的被动相关性。我们提出了这样一种可能性，即 COMT 基因的遗传驱动变异可能与儿童期创伤相互作用，从而增加发展为分裂型人格特质的风险。
