Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, 8000 Aarhus, Denmark.
Genes (Basel). 2022 Jun 10;13(6):1038. doi: 10.3390/genes13061038.
Bipolar disorder is a debilitating psychiatric condition that is shaped in a concerted interplay between hereditary and triggering risk factors. Profound depression and mania define the disorder, but high clinical heterogeneity among patients complicates diagnosis as well as pharmacological intervention. Identification of peripheral biomarkers that capture the genomic response to the exposome may thus progress the development of personalized treatment. MicroRNAs (miRNAs) play a prominent role in of post-transcriptional gene regulation in the context of brain development and mental health. They are coordinately modulated by multifarious effectors, and alteration in their expression profile has been reported in a variety of psychiatric conditions. Intriguingly, miRNAs can be released from CNS cells and enter circulatory bio-fluids where they remain remarkably stable. Hence, peripheral circulatory miRNAs may act as bio-indicators for the combination of genetic risk, environmental exposure, and/or treatment response. Here we provide a comprehensive literature search and data mining approach that summarize current experimental evidence supporting the applicability of miRNAs for patient stratification in bipolar disorder.
双相情感障碍是一种使人衰弱的精神疾病，它是由遗传和触发风险因素共同作用形成的。严重的抑郁和躁狂定义了这种疾病，但患者之间存在高度的临床异质性，这使得诊断和药物干预变得复杂。因此，识别能够捕捉外显子组对基因组反应的外周生物标志物，可能会推动个性化治疗的发展。 microRNAs (miRNAs) 在脑发育和心理健康的背景下，在转录后基因调控中发挥着重要作用。它们受到多种效应物的协调调节，并且在多种精神疾病中已经报道了它们的表达谱发生改变。有趣的是，miRNAs 可以从中枢神经系统细胞中释放出来，并进入循环生物液中，在那里它们仍然非常稳定。因此，外周循环中的 miRNAs 可以作为遗传风险、环境暴露和/或治疗反应的综合生物标志物。在这里，我们提供了一种全面的文献搜索和数据挖掘方法，总结了目前支持 miRNAs 用于双相情感障碍患者分层的实验证据。
