Appelmann Iris, Liersch Rüediger, Kessler Torsten, Mesters Rolf M, Berdel Wolfgang E
Department of Medicine/Hematology and Oncology, University of Münster, Albert-Schweitzer-Strasse 33, 48129, Münster, Germany.
Recent Results Cancer Res. 2010;180:51-81. doi: 10.1007/978-3-540-78281-0_5.
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in a variety of in vivo models. VEGF gene transcription is induced in particular in hypoxic cells. In developmental angiogenesis, the role of VEGF is demonstrated by the finding that the loss of a single VEGF allele results in defective vascularization and early embryonic lethality. Substantial evidence also implicates VEGF as a mediator of pathological angiogenesis. In situ hybridization studies demonstrate expression of VEGF mRNA in the majority of human tumors. Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for connective tissue, and also has important roles during embryonal development. Its overexpression has been linked to different types of malignancies. Thus, it is important to understand the physiology of VEGF and PDGF and their receptors as well as their roles in malignancies in order to develop antiangiogenic strategies for the treatment of malignant disease.
血管内皮生长因子（VEGF）在体外是一种内皮细胞特异性促有丝分裂原，在多种体内模型中是血管生成诱导剂。VEGF基因转录尤其在缺氧细胞中被诱导。在发育性血管生成中，VEGF的作用通过以下发现得以证明：单个VEGF等位基因缺失会导致血管形成缺陷和早期胚胎致死。大量证据还表明VEGF是病理性血管生成的介质。原位杂交研究表明VEGF mRNA在大多数人类肿瘤中表达。血小板衍生生长因子（PDGF）主要被认为是结缔组织的重要促有丝分裂原，在胚胎发育过程中也具有重要作用。其过表达与不同类型的恶性肿瘤有关。因此，了解VEGF和PDGF及其受体的生理学以及它们在恶性肿瘤中的作用，对于开发治疗恶性疾病的抗血管生成策略非常重要。
