Pratt C B, Rivera G, Shanks E, Johnson W W, Howarth C, Terrell W, Kumar A P
Cancer. 1977 Nov;40(5 Suppl):2464-72. doi: 10.1002/1097-0142(197711)40:5+<2464::aid-cncr2820400912>3.0.co;2-d.
Between October, 1974 and December, 1976, 13 adolescent patients with far-advanced, poorly differentiated colorectal carcinoma had been referred to a pediatric cancer center. All patients received chemotherapy with vincristine, methyl-CCNU and 5-fluorouracil. Five of 13 patients are living, one of whom remains disease-free after 12 months of chemotherapy. Four of the patients were from urban areas and nine from rural areas. One of four from urban areas had intimate exposure to chemicals used in the production of cotton and soy beans. Eight of nine patients from rural areas also had exposure to farm or agricultural chemicals, and three of these patients were intimately involved with the spraying operations. Suggestions regarding etiology and causative factors for the development of carcinoma of the colon in adults have previously been advanced. Results of these studies suggest that alternate etiologies must be suggested for adolescent colorectal carcinoma.
1974年10月至1976年12月期间，13例患有晚期低分化结直肠癌的青少年患者被转诊至一家儿科癌症中心。所有患者均接受了长春新碱、甲基环己亚硝脲和5-氟尿嘧啶化疗。13例患者中有5例存活，其中1例在化疗12个月后仍无疾病。4例患者来自城市地区，9例来自农村地区。城市地区的4例患者中有1例密切接触了棉花和大豆生产中使用的化学品。农村地区的9例患者中有8例也接触过农用或农业化学品，其中3例患者密切参与了喷洒作业。此前已提出关于成人结肠癌发生的病因和致病因素的建议。这些研究结果表明，必须为青少年结直肠癌提出其他病因。
