Suppr超能文献

核糖核苷酸还原酶抑制剂可减轻双损伤兔模型中的动脉粥样硬化。

Ribonucleotide reductase inhibitors reduce atherosclerosis in a double-injury rabbit model.

作者信息

Gallaugher Laura D, Henry Jon C, Kearns Patrick N, Elford Howard L, Bergdall Valerie K, Cardounel Arturo J

机构信息

Division of University Laboratory Animal Resources and the Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio, USA.

出版信息

Comp Med. 2009 Dec;59(6):567-72.

Abstract

Atheroproliferative disorders such as atherosclerosis are an important health problem and one of the leading causes of morbidity and mortality in the United States. Minimally invasive therapeutic procedures, including angioplasty with stent deployment, are used frequently for obstructive coronary artery disease. However, restenosis, a proliferative vascular response, is a common sequela to this procedure. The current study investigated the effect of inhibiting ribonucleotide reductase (RR), an enzyme necessary for cellular proliferation, in an attempt to ameliorate the proliferative response. Two RR inhibitors, didox and hydroxyurea, were chosen for their potent antiproliferative properties. Studies were carried out by using a double-injury rabbit model, in which endothelial denudation was followed by the administration of a high-fat diet. At 4 wk after initial endothelial denudation, the developing atherosclerotic lesion was subjected to transluminal balloon dilation to simulate clinical intervention with percutaneous transluminal angioplasty. The degree of restenosis and atheroproliferation was assessed at 8 wk. Histologic evaluation of the lesion demonstrated that treatment with didox and hydroxyurea significantly decreased lesion area and lumen loss. These results suggest that RR inhibition may be an effective new tool for the treatment of atheroproliferative disorders.

摘要

动脉粥样硬化等动脉粥样增生性疾病是一个重要的健康问题,也是美国发病和死亡的主要原因之一。包括血管成形术并植入支架在内的微创治疗程序常用于治疗阻塞性冠状动脉疾病。然而,再狭窄是一种血管增殖反应,是该治疗程序常见的后遗症。当前的研究调查了抑制核糖核苷酸还原酶(RR)(一种细胞增殖所必需的酶)的效果,以试图改善增殖反应。选择了两种RR抑制剂——双吖啶和羟基脲,因其具有强大的抗增殖特性。研究采用双损伤兔模型进行,先进行内皮剥脱,随后给予高脂饮食。在初次内皮剥脱后4周,对正在形成的动脉粥样硬化病变进行腔内球囊扩张,以模拟经皮腔内血管成形术的临床干预。在8周时评估再狭窄和动脉粥样增生的程度。对病变的组织学评估表明,双吖啶和羟基脲治疗显著减少了病变面积和管腔狭窄。这些结果表明,抑制RR可能是治疗动脉粥样增生性疾病的一种有效的新方法。

相似文献

2
Inhibition of ribonucleotide reductase reduces neointimal formation following balloon injury.
J Pharmacol Exp Ther. 2005 Jul;314(1):70-6. doi: 10.1124/jpet.105.083980. Epub 2005 Apr 6.
6
The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML.
PLoS One. 2014 Nov 17;9(11):e112619. doi: 10.1371/journal.pone.0112619. eCollection 2014.
8

引用本文的文献

1
Targeting the Cell Cycle, RRM2 and NF-κB for the Treatment of Breast Cancers.
Cancers (Basel). 2024 Feb 28;16(5):975. doi: 10.3390/cancers16050975.
3
The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML.
PLoS One. 2014 Nov 17;9(11):e112619. doi: 10.1371/journal.pone.0112619. eCollection 2014.
4
Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.
Antioxid Redox Signal. 2013 Apr 1;18(10):1165-207. doi: 10.1089/ars.2011.4322. Epub 2012 Jun 26.

本文引用的文献

2
Drug-eluting stent thrombosis: it's never too late.
Nat Clin Pract Cardiovasc Med. 2006 Dec;3(12):638-9. doi: 10.1038/ncpcardio0720.
4
Comparison of long-term (seven year) outcomes among patients undergoing percutaneous coronary revascularization with versus without stenting.
Am J Cardiol. 2006 May 15;97(10):1467-72. doi: 10.1016/j.amjcard.2005.12.036. Epub 2006 Mar 29.
5
Inhibition of ribonucleotide reductase reduces neointimal formation following balloon injury.
J Pharmacol Exp Ther. 2005 Jul;314(1):70-6. doi: 10.1124/jpet.105.083980. Epub 2005 Apr 6.
7
Prevention of restenosis after coronary angioplasty.
Curr Opin Cardiol. 2004 Sep;19(5):500-9. doi: 10.1097/01.hco.0000133658.77024.59.
8
Novel approaches to reduce restenosis.
Ann N Y Acad Sci. 2004 May;1015:367-78. doi: 10.1196/annals.1302.032.
10
New approaches to preventing restenosis.
BMJ. 2003 Aug 2;327(7409):274-9. doi: 10.1136/bmj.327.7409.274.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验