The Retreat Hospital, York, UK.
Neurosci Biobehav Rev. 2010 Jul;34(8):1121-36. doi: 10.1016/j.neubiorev.2009.12.009. Epub 2009 Dec 23.
Recent advances in understanding hippocampal information processing offer new vistas on the mind-body and binding problems. Information encoded by the autoassociation network of cornu ammonis 3 (CA3) situates landmarks and objects within an allocentric framework of space and time. Guiding locomotion across the spatial environment, and generally organizing behaviour that transcends space and time, the hippocampus creates phenomenal space and time themselves, thus laying the foundations for conscious awareness. It is argued that conscious experience describes/symbolizes the informational content of self-organizing activity patterns in CA3. Imagery, conscious perception or hallucinations do not in themselves affect the physical trajectory of behaviour but are evidence for patterns of neuronal activity that, acting via the medial prefrontal cortex, modulate action dispositions and influence prefrontal top-down attentional control of sensory processing and thus subsequent event memory formation. Evidence for GABAergic deficit and pyramidal cell hyperexcitability in CA3 in patients with schizophrenia is consistent with the notion that binding, by the CA3 network, of cortical modules representing weakly related sensory representations underlies hallucinations in this disorder.
理解海马体信息处理的最新进展为身心问题和绑定问题提供了新的视角。由角回 3（CA3）的自联想网络编码的信息将地标和物体定位在空间和时间的非局部框架内。引导在空间环境中的运动，并通常组织超越空间和时间的行为，海马体本身创造了现象空间和时间，从而为意识意识奠定了基础。有人认为，意识体验描述/象征着 CA3 中自我组织活动模式的信息内容。意象、有意识的感知或幻觉本身并不会影响行为的物理轨迹，但它们是神经元活动模式的证据，这些活动模式通过内侧前额叶皮层发挥作用，调节动作倾向，并影响前额叶自上而下的注意力控制对感官处理的影响，从而影响随后的事件记忆形成。精神分裂症患者 CA3 中 GABA 能缺陷和锥体神经元过度兴奋的证据与以下观点一致，即 CA3 网络将代表弱相关感觉表象的皮质模块绑定在一起，是该疾病产生幻觉的基础。
