Agric Chem Dept, Agric College, Minia University, Egypt.
Food Chem Toxicol. 2010 Mar;48(3):803-6. doi: 10.1016/j.fct.2009.12.011. Epub 2009 Dec 23.
Liver disorders are one of the common recent problems affects on the human health. These disorders due to many environmental polluted sources. Many herbal, medicinal and pharmaceutical plants and their extracts are widely studied by many researchers. Silybum marianum got a bright reputation in relieve the liver diseases, and that might be for the potent silymarin mixture. Mechanism of action for silymarin conducted mainly to the antiradical and anticarcinogenic roles. Ethyl acetate (100mg/kg bw) and ethanol seed extracts for S. marianum (100mg/kg bw) were tested against the injection (i.p.) by carbon tetrachloride (2 ml/kg bw) the inducer of liver damage. Their activity were compared with standard hepatic drug hepaticum (100mg/kg bw) for 10 days. Ethanolic extract showed the most significantly decrease in the liver enzymes. For the oxidative experiments, ethyl acetate showed the most increase for glutathione level and the risk factor HDL/LDL significantly. Hepaticum was the most powerful group for the significant decreasing for malondialdehyde and fucosidase activity. Some equal improvements were noticed in the histopathological studies for the protective groups.
肝脏疾病是影响人类健康的常见问题之一。这些疾病是由于许多环境污染源引起的。许多草药、药用和制药植物及其提取物被许多研究人员广泛研究。水飞蓟素因其对肝脏疾病的有效缓解作用而备受赞誉，这可能是因为其含有强效的水飞蓟素混合物。水飞蓟素的作用机制主要是通过抗氧化和抗癌作用。乙酸乙酯（100mg/kg bw）和乙醇种子提取物（100mg/kg bw）用于测试对碳四氯化物（2ml/kg bw）诱导的肝损伤的腹腔内注射。它们的活性与标准肝药肝片（100mg/kg bw）进行了 10 天的比较。乙醇提取物对肝酶的降低作用最为显著。对于氧化实验，乙酸乙酯显示出最高的谷胱甘肽水平和 HDL/LDL 风险因素的增加。肝片是降低丙二醛和岩藻糖苷酶活性最有效的组。在组织病理学研究中也观察到了一些相等的改善。
