School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2018 Oct;32(10):1933-1949. doi: 10.1002/ptr.6153. Epub 2018 Jul 17.
Metabolic syndrome describes a complex metabolic risk factors including obesity, hypertension, dyslipidemia, and diabetes. This syndrome is diagnosed by medical conditions such as weight gain, high blood pressure, high blood glucose, and disturbance in lipid profile. Metabolic syndrome has become as an important and increasing global health problem, so finding potentially novel solutions with less adverse effects is favorable for health problems. Herbal therapy plays an important role for treatment of different diseases. Silybum marianum is a plant that is used for centuries as a herbal treatment in liver and biliary tract diseases. Silymarin is the main component of S. marianum and derived from fruits and seeds of S. marianum (milk thistle). S. marianum has been found to exhibit antioxidant, lipid-lowering, antihypertensive, antidiabetic, antiatherosclerotic, anti-obesity, and hepatoprotective effects. Therefore, the aim of this review is to summarize different animal and human studies regarding the effect of S. marianum in metabolic syndrome and to identify the underlying mechanisms of action.
代谢综合征描述了一系列复杂的代谢危险因素，包括肥胖、高血压、血脂异常和糖尿病。该综合征通过体重增加、高血压、高血糖和血脂谱紊乱等医学状况来诊断。代谢综合征已成为一个重要且日益严重的全球健康问题，因此寻找潜在的新型解决方案，减少不良反应，有利于解决健康问题。草药疗法在治疗各种疾病方面发挥着重要作用。水飞蓟是一种植物，几个世纪以来一直被用作治疗肝脏和胆道疾病的草药。水飞蓟素是水飞蓟的主要成分，来源于水飞蓟的果实和种子（奶蓟草）。已经发现水飞蓟具有抗氧化、降低血脂、降压、降血糖、抗动脉粥样硬化、抗肥胖和保肝作用。因此，本综述的目的是总结不同的动物和人体研究，探讨水飞蓟对代谢综合征的影响，并确定其作用机制。
