在野油菜黄单胞菌中，PmrAB 系统使病原体更容易受到多黏菌素 B 的影响，并对过量的铁更有抵抗力。
The PmrAB system in Erwinia amylovora renders the pathogen more susceptible to polymyxin B and more resistant to excess iron.
机构信息
Department of Crop Sciences, University of Illinois at Urbana-Champaign, 1201 W. Gregory Drive, 288A ERML, Urbana, IL 61801, USA.
出版信息
Res Microbiol. 2010 Mar;161(2):153-7. doi: 10.1016/j.resmic.2009.12.001. Epub 2009 Dec 23.
The PmrAB system is a two-component regulatory system that responds to extracellular iron and acidic pH. The role of the PmrAB system in Erwinia amylovora remains unknown so far. Our results showed that the pmrAB mutants were more resistant to strong acidic conditions than the wild type (WT) strain. The survival rate of the pmrAB mutants was much higher than that of WT when treated with polymyxin B. However, pmrAB mutants were more sensitive to extracellular iron than WT strain. These results demonstrated that the PmrAB system in E. amylovora renders the pathogen more susceptible to polymyxin B and acidic pH, but more resistance to excess iron.
PmrAB 系统是一种对细胞外铁和酸性 pH 做出响应的双组分调控系统。迄今为止，PmrAB 系统在果胶肠杆菌中的作用尚不清楚。我们的结果表明，与野生型（WT）菌株相比，pmrAB 突变体在强酸条件下的抗性更强。在用多黏菌素 B 处理时，pmrAB 突变体的存活率比 WT 菌株高得多。然而，pmrAB 突变体对外源铁的敏感性比 WT 菌株高。这些结果表明，果胶肠杆菌中的 PmrAB 系统使病原体更容易受到多黏菌素 B 和酸性 pH 的影响，但对过量铁的抵抗力更强。
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