Department of Chemistry, National Institute of Technology, Kurukshetra 136 119, India.
Eur J Med Chem. 2010 Mar;45(3):1230-6. doi: 10.1016/j.ejmech.2009.12.009. Epub 2010 Jan 19.
A novel series of macrocyclic complexes of the type [M(C(18)H(14)N(10)S(2))X]X(2) where M=Cr(III), Fe(III) and Mn(III); X=Cl(-), NO(3)(-) and CH(3)COO(-) have been synthesized by [2+2] condensation of thiocarbohydrazide and isatin in the presence of trivalent metal salts in methanolic medium by template method. The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic measurements, electronic, NMR, IR and mass spectral studies. On the basis of these studies, a five coordinate square pyramidal geometry for all of these complexes has been proposed. These metal complexes were also tested for their in vitro antimicrobial activities against some bacterial strains viz. Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and some fungal strains Aspergillus niger, Aspergillus flavus (molds), Candida albicans, Saccharomyces cerevisiae (yeasts).
新型大环配合物系列[M(C(18)H(14)N(10)S(2))X]X(2)，其中 M=Cr(III)、Fe(III)和 Mn(III)；X=Cl(-)、NO(3)(-)和 CH(3)COO(-)，通过模板法在甲醇介质中用三价金属盐，由硫代碳酰肼和靛红的[2+2]缩合反应合成。配合物通过元素分析、电导测量、磁性测量、电子、NMR、IR 和质谱研究进行了表征。根据这些研究，提出了所有这些配合物的五配位四方锥几何结构。还测试了这些金属配合物对一些细菌菌株（金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌）和一些真菌菌株（黑曲霉、黄曲霉（霉菌）、白色念珠菌、酿酒酵母（酵母））的体外抗菌活性。
