Paclt Ivo, Koudelová Jitka, Pacltova Dagmar, Kopeckova Marta
Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague and General Teaching Hospital, Czech Republic.
Neuro Endocrinol Lett. 2009;30(5):604-9.
Developmental study of dopaminergic and noradrenergic systems in child psychiatric disorders are rare. DBH activity is one of noradrenergic biochemical marker that is correlate in psychiatry to clinical and genetic data.
The main aim of the present study was to measure DBH activity at the onset of acute schizophrenia and depressive disorder in children and adolescents without pharmacological treatment and to compare these values with DBH activity in healthy controls. The authors also investigated untreated ADHD children.
We examined 42 control healthy children, 15 children non-treated with acute schizophrenia, 15 non-treated children with acute depressive disorders and 30 non-treated ADHD children, all in age 7-14. Plasma DBH level was provided by Nagatsu (1972; 1974). Depressed children were reexamined after clinical remission.
DBH activity is statistically significantly decreased in non-treated depressive disorder and ADHD in children and adolescents. DBH activity is normalised during antidepressant therapy in child depression. Child schizophrenia patients present with normal DBH activity.
These results are similar to the results that have been observed in adult patients with schizophrenia and depression and in previous studies of DBH activity in children with ADHD. These results also indicate hypoactivity of the noradrenergic system in children with ADHD and depression.
儿童精神疾病中多巴胺能和去甲肾上腺素能系统的发育研究很少见。多巴胺β羟化酶（DBH）活性是去甲肾上腺素能生化标志物之一，在精神病学中与临床和遗传数据相关。
本研究的主要目的是测量未经药物治疗的儿童和青少年急性精神分裂症和抑郁症发作时的DBH活性，并将这些值与健康对照者的DBH活性进行比较。作者还对未经治疗的注意缺陷多动障碍（ADHD）儿童进行了调查。
我们检查了42名健康对照儿童、15名未经治疗的急性精神分裂症儿童、15名未经治疗的急性抑郁症儿童和30名未经治疗的ADHD儿童，年龄均在7至14岁之间。血浆DBH水平由长津（1972年；1974年）提供。抑郁症儿童在临床缓解后再次接受检查。
未经治疗的儿童和青少年抑郁症及ADHD患者的DBH活性在统计学上显著降低。儿童抑郁症患者在抗抑郁治疗期间DBH活性恢复正常。儿童精神分裂症患者的DBH活性正常。
这些结果与在成年精神分裂症和抑郁症患者以及先前对ADHD儿童DBH活性的研究中观察到的结果相似。这些结果还表明ADHD和抑郁症儿童的去甲肾上腺素能系统功能低下。
