Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, 430030 Wuhan, China.
Rheumatol Int. 2011 Apr;31(4):513-9. doi: 10.1007/s00296-009-1249-0. Epub 2009 Dec 25.
Programmed death ligand (PDL) is a new member of the B7 family of costimulatory molecules that specifically interacts with programmed death 1 (PD-1) expressed on activated T cells, B cells, and myeloid cells. Collagen II (CII)-induced arthritis (CIA) is an experimental model of arthritis that has been used to dissect the pathogenesis of human rheumatoid arthritis. In this study, we have investigated the effects of PDL-Ig on CIA. Administration of PDL-Ig significantly ameliorated the disease as assessed by clinical arthritis score and histology in the joints. Expression of proinflammatory cytokines, such as IL-17 and IL-23, in the serum was reduced by PDL-Ig treatment. These results showed a beneficial effect of PDL-Ig on CIA through anti-inflammatory actions and inhibition of cell proliferation in response to CII, suggesting that the PD-1-PDL pathway may be involved in the pathogenesis of CIA, and thus PDL-Ig may be a useful therapy for the improvement of human rheumatoid arthritis.
程序性死亡配体 (PDL) 是 B7 家族共刺激分子的新成员，特异性地与表达于活化的 T 细胞、B 细胞和髓系细胞表面的程序性死亡受体 1 (PD-1) 相互作用。胶原诱导性关节炎 (CIA) 是一种关节炎的实验模型，被用于解析人类类风湿关节炎的发病机制。在本研究中，我们研究了 PDL-Ig 对 CIA 的作用。PDL-Ig 的给药通过临床关节炎评分和关节组织学评估明显改善了疾病。PDL-Ig 治疗降低了血清中促炎细胞因子（如 IL-17 和 IL-23）的表达。这些结果表明，PDL-Ig 通过抗炎作用和抑制对 CII 的细胞增殖对 CIA 产生有益效果，提示 PD-1-PDL 途径可能参与 CIA 的发病机制，因此 PDL-Ig 可能是改善人类类风湿关节炎的一种有用的治疗方法。
