[From the ancient serotherapy to naked antibodies: a century of successful targeted therapies].

Monoclonal antibodies and molecular engineering have renewed the ancient serotherapy, multiplying the possibilities of therapeutic interventions and providing many new clinical successes! Standing back about this history allows us to better understand the evolution of concepts underlying the therapeutic use of antibodies, as well as the maturation of the tool itself. The different principles of therapeutic targeting will be successively tackled, from their sometimes hundred year-old conception until the most recent clinical developments: antibodies neutralizing toxins and soluble antigens, anti-microbial antibodies, cytotoxic antibodies, tumour-specific antibodies, cell function -modifying antibodies, etc. This overview will finally offer the opportunity to introduce a new pharmacological classification of the entire class of unconjugated -therapeutic antibodies.