Division of Pediatric Urology, Department of Urology, Ankara University School of Medicine, Ankara, Turkey.
Urology. 2010 Jul;76(1):169-74. doi: 10.1016/j.urology.2009.09.080. Epub 2009 Dec 29.
To compare ultrasound (US) scan and nuclear renography findings in patients who underwent pyeloplasty with and without pelvic reduction in a randomized prospective study.
A total of 42 patients, all prenatally diagnosed with unilateral hydronephrosis, were included. Hydronephrosis was confirmed postnatally. Twenty patients were randomly selected to undergo pyeloplasty with pelvic reduction and 22 underwent pelvis-sparing pyeloplasty. Patients were evaluated with mercaptoacetyltriglycine-3 scans on the sixth month and US scans on the first, third, and sixth months, postoperatively. Mean follow-up was 37 +/- 5.6 weeks. Statistical analyses were performed using chi-square test and significance was set as P <.05. Power analyses were performed by the NCSS-PASS program. Power value of 0.84 was calculated for a sample size of 42.
The anteroposterior pelvic diameter decreased significantly in the pelvic reduction group compared with pelvis-sparing group in the first- and third-month US scans. However, the difference was not significant in the sixth month. The improvements in the US findings for the pelvis-sparing group match with those of the pelvic reduction group later in the postoperative period. Pelvic reduction significantly improved the renal washout time (T(1/2)) in mercaptoacetyltriglycine-3 renography when compared with pyeloplasty group without reduction at postoperative sixth month. Differential renal function was found to be unaffected from pelvic reduction.
Resolution of anteroposterior diameter in US scan is more prominent in the pelvic reduction group at earlier stages of the postoperative period. Although T(1/2) decreases more prominently in the pelvic reduction group, the utility of this procedure is still indecisive. This feature can reveal possible surgical failures earlier and strengthen the values of US and renography postoperatively.
在一项随机前瞻性研究中,比较肾盂成形术伴与不伴骨盆缩小术患者的超声(US)扫描和核肾图检查结果。
共纳入 42 例患者,均为单侧肾积水的产前诊断患者。产后确认肾积水。随机选择 20 例患者行肾盂成形术伴骨盆缩小术,22 例行保留骨盆的肾盂成形术。术后第 6 个月行巯基乙酰三甘氨酸-3 扫描,第 1、3、6 个月行 US 扫描。平均随访 37 +/- 5.6 周。采用卡方检验进行统计学分析,以 P <.05 为差异有统计学意义。采用 NCSS-PASS 程序进行功效分析。计算样本量为 42 时的功效值为 0.84。
与保留骨盆组相比,骨盆缩小组在术后第 1、3 个月的 US 扫描中骨盆前后径显著减小。然而,在第 6 个月时差异无统计学意义。保留骨盆组的 US 检查结果改善与术后后期骨盆缩小组相似。与无骨盆缩小的肾盂成形术组相比,骨盆缩小术在术后第 6 个月时明显改善了巯基乙酰三甘氨酸-3 肾图的肾洗脱时间(T1/2)。未发现骨盆缩小术对分肾功能有影响。
在术后早期,骨盆缩小组的 US 扫描前后径分辨率更为显著。尽管骨盆缩小组的 T1/2 下降更为明显,但该手术的效果仍不确定。这一特征可以更早地揭示可能的手术失败,并加强术后 US 和肾图的价值。