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肾盂输尿管连接部梗阻中肾盂离断性整形术的复位与非复位疗效分析:一项随机、前瞻性、对照研究

Outcome Analysis of Reduction and Nonreduction Dismembered Pyeloplasty in Ureteropelvic Junction Obstruction: A Randomized, Prospective, Comparative Study.

作者信息

Yhoshu Enono, Menon Prema, Rao Katragadda Lakshmi Narasimha, Bhattacharya Anish

机构信息

Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

J Indian Assoc Pediatr Surg. 2022 Jan-Feb;27(1):25-31. doi: 10.4103/jiaps.JIAPS_229_20. Epub 2022 Jan 11.

Abstract

OBJECTIVES

The objective of this study is to compare the changes in renal function and drainage following open dismembered pyeloplasty with and without renal pelvis reduction.

MATERIALS AND METHODS

Randomized prospective study of children with ureteropelvic junction obstruction undergoing pyeloplasty with (Group 1) and without (Group 2) pelvis reduction over an 18-month period. Postoperative function and drainage were assessed by ethylene dicysteine (EC) scan and intravenous urography (IVU) and renal pelvis size by ultrasonography.

RESULTS

Forty-two patients (2 months-11 years) participated. The mean preoperative EC scan function was Group 1: 45.88% ± 14.42% (5%-80%) and Group 2: 39.22% ± 9.75% (21%-53%). ( = 0.117). The mean postoperative EC scan function of Group 1 was 42.64% ± 9.62% (17%-54%) and 43.75% ± 9.88% (17%-58%) and of Group 2 was 44.77% ± 12.82% (20%-68%) and 42.25% ± 8.56% (23%-58%) at 3 months ( = 0.584) and ≥ 1year ( = 0.385), respectively, with no significant difference. None required re-do pyeloplasty. The number of patients with slow drainage, especially at 3 months and also at ≥1-year postoperative period on EC scan was slightly higher in Group 2 compared to Group 1 but did not attain statistical significance. There was postoperative improvement in function and drainage on IVU with no significant difference between the two groups, ( = 0.214; = 0.99, respectively). At a mean follow-up of 45.5 months, Group 2 also showed significant reduction in pelvis size on ultrasound ( = 0.011).

CONCLUSION

Postoperative function remained stable in both groups. More number of patients achieved unobstructed drainage by 3 mo postoperative after reduction pyeloplasty but drainage patterns were mostly similar between reduction and nonreduction of pelvis group in late follow-up.

摘要

目的

本研究的目的是比较开放式离断性肾盂成形术在有和没有肾盂缩小情况下肾功能和引流的变化。

材料与方法

对输尿管肾盂连接部梗阻的儿童进行为期18个月的随机前瞻性研究,其中一组(第1组)进行肾盂成形术时行肾盂缩小,另一组(第2组)不行肾盂缩小。术后通过二巯基乙烷(EC)扫描和静脉肾盂造影(IVU)评估肾功能和引流情况,通过超声检查评估肾盂大小。

结果

42例患者(2个月至11岁)参与研究。术前EC扫描的平均肾功能,第1组为45.88%±14.42%(5% - 80%),第2组为39.22%±9.75%(21% - 53%)(P = 0.117)。第1组术后3个月EC扫描的平均肾功能为42.64%±9.62%(17% - 54%),≥1年时为43.75%±9.88%(17% - 58%);第2组术后3个月为44.77%±12.82%(20% - 68%),≥1年时为42.25%±8.56%(23% - 58%),两组之间均无显著差异。无一例需要再次进行肾盂成形术。第2组在EC扫描中引流缓慢的患者数量,尤其是在术后3个月及≥1年时,略高于第第1组,但未达到统计学意义。IVU显示术后肾功能和引流均有改善,两组之间无显著差异(P分别为0.214和0.99)。平均随访45.5个月时第2组超声检查显示肾盂大小也有显著缩小(P = 0.011)。

结论

两组术后肾功能均保持稳定。肾盂成形术缩小肾盂组术后3个月时更多患者实现了通畅引流,但在后期随访中,肾盂缩小组和未缩小组的引流模式大多相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da9/8853589/05f47ddac25b/JIAPS-27-25-g001.jpg

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