Ezrin 是 CCL25/CCR9 诱导的 MOLT4 细胞转移中的关键分子。
Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9.
机构信息
Department of Immunology, College of Basic Medical Science, Wuhan University, Wuhan, Hubei, China.
出版信息
Leuk Res. 2010 Jun;34(6):769-76. doi: 10.1016/j.leukres.2009.11.025. Epub 2009 Dec 24.
Chemokines and their corresponding receptors participate in transmigration of leukemic cells. ERM (ezrin/radixin/moesin) protein family act as linkers between the plasma membrane and the cytoskeleton and are key component in tumor metastasis. In this study we used the CCR9-expressing acute T lymphocytic cell line MOLT4 as a model and assesssed their morphological and functional changes in response to CCL25. The pseudopodium formed and ERM translocated from the cytoplasm to the cell membrane following treatment with CCL25. Ezrin silencing by miRNA showed that ezrin plays important roles in the polarization and invasive behaviour of MOLT4 cells.
趋化因子及其相应的受体参与白血病细胞的迁移。ERM（ezrin/radixin/moesin）蛋白家族作为质膜和细胞骨架之间的连接物，是肿瘤转移的关键组成部分。在这项研究中，我们使用表达 CCR9 的急性 T 淋巴细胞系 MOLT4 作为模型，评估了它们对 CCL25 的反应的形态和功能变化。CCL25 处理后，伪足形成，ERM 从细胞质转移到细胞膜。miRNA 沉默 ezrin 表明 ezrin 在 MOLT4 细胞的极化和侵袭行为中发挥重要作用。
Zotero 插件