Department of Pathology, Rush University, Chicago, USA.
Cancer Lett. 2010 Jun 28;292(2):171-5. doi: 10.1016/j.canlet.2009.11.022. Epub 2009 Dec 29.
Human Papillomaviruses (HPVs) have been found in association with benign and malignant growth of epithelia. The cell cycle inhibitor p16(Ink4a) has been shown to be overexpressed in HPV-positive cervical pre-malignant and malignant lesions, probably as a result of pRB targeting by the viral E7 protein. Inverted papillomas of the urinary bladder are epithelial tumors considered to be of benign nature. In this report we analyze the expression of p16(Ink4a) and the presence of HPV sequences in inverted papillomas and in non-tumoral bladder controls. Our results show no association of HPV infection and inverted papillomas. Further, no correlation between p16 overexpression and HPV positivity was found. We conclude that HPV does not play an indispensable role in the development of urinary bladder inverted papillomas and that overexpression of p16(Ink4a) does not correlate with HPV infection in these tumors.
人乳头瘤病毒（HPV）已被发现与上皮的良性和恶性生长有关。细胞周期抑制剂 p16（Ink4a）已被证明在 HPV 阳性的宫颈前恶性和恶性病变中过度表达，可能是由于病毒 E7 蛋白靶向 pRB。膀胱内翻性乳头状瘤是被认为具有良性性质的上皮肿瘤。在本报告中，我们分析了 p16（Ink4a）的表达和 HPV 序列在膀胱内翻性乳头状瘤和非肿瘤性膀胱对照中的存在。我们的结果显示 HPV 感染与内翻性乳头状瘤无关。此外，p16 过表达与 HPV 阳性之间也没有相关性。我们得出结论，HPV 在膀胱内翻性乳头状瘤的发生发展中不起不可或缺的作用，并且 p16（Ink4a）的过表达与这些肿瘤中的 HPV 感染无关。
