Biophysics Group, BIOTEC, TU Dresden, Dresden, Germany.
FEBS Lett. 2010 May 3;584(9):1653-8. doi: 10.1016/j.febslet.2009.12.036. Epub 2009 Dec 27.
Membranes with simple lipid composition exhibit complex phase behavior. Ordered and disordered liquid phases can coexist in cholesterol-containing membranes with lipid compositions resembling biological membranes and at physiological temperatures. Research during the last years suggests that these lipid domains play a role in the organization of biological membranes. Understanding the principles that govern the formation and stability of lipid domains is of great importance to build a model that properly describes membrane structure and function. In this review, we describe the current knowledge of the chemical and physical basis of lipid domains and its application to biological membranes.
具有简单脂质组成的膜表现出复杂的相行为。在含有胆固醇的膜中，脂质组成类似于生物膜，在生理温度下，有序相和无序相可以共存。近年来的研究表明，这些脂质域在生物膜的组织中发挥作用。理解控制脂质域形成和稳定性的原则对于构建一个能够正确描述膜结构和功能的模型非常重要。在这篇综述中，我们描述了脂质域的化学和物理基础及其在生物膜中的应用的现有知识。
