Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX
Department of Physiology and Biophysics, University of Washington, Seattle, WA.
J Gen Physiol. 2018 Feb 5;150(2):211-224. doi: 10.1085/jgp.201711875. Epub 2018 Jan 11.
Lipids influence powerfully the function of ion channels and transporters in two well-documented ways. A few lipids act as bona fide second messengers by binding to specific sites that control channel and transporter gating. Other lipids act nonspecifically by modifying the physical environment of channels and transporters, in particular the protein-membrane interface. In this short review, we first consider lipid signaling from this traditional viewpoint, highlighting innumerable publications that have contributed to our present understanding. We then switch to our own emerging view that much important lipid signaling occurs via the formation of membrane domains that influence the function of channels and transporters within them, promote selected protein-protein interactions, and control the turnover of surface membrane.
脂质通过两种已被充分证实的方式强烈影响离子通道和转运体的功能。少数脂质通过与控制通道和转运体门控的特定位点结合而充当真正的第二信使。其他脂质通过改变通道和转运体的物理环境（特别是蛋白质-膜界面）而发挥非特异性作用。在这篇简短的综述中，我们首先从这个传统观点来考虑脂质信号转导，强调有无数出版物为我们目前的理解做出了贡献。然后，我们转向自己正在出现的观点，即许多重要的脂质信号转导是通过形成影响其中通道和转运体功能的膜域来发生的，促进选定的蛋白质-蛋白质相互作用，并控制细胞膜表面的周转率。
