难治性淋巴细胞性小肠结肠炎和肿瘤坏死因子拮抗剂治疗。
Refractory lymphocytic enterocolitis and tumor necrosis factor antagonist therapy.
机构信息
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Clin Gastroenterol Hepatol. 2010 Apr;8(4):391-4. doi: 10.1016/j.cgh.2009.12.010. Epub 2009 Dec 28.
Abstract
BACKGROUND & AIMS: Lymphocytic enterocolitis is a malabsorptive syndrome characterized by severe small-bowel villous abnormality and crypt hyperplasia and dense infiltrate of lymphocytes throughout the gastrointestinal tract.
METHODS
We present 2 patients with lymphocytic enterocolitis refractory to usual medical therapy who were treated with tumor necrosis factor antagonists.
RESULTS
Both patients had clinical improvement in diarrheal symptoms and intestinal histologic abnormalities.
CONCLUSIONS
Tumor necrosis factor-alpha antagonists such as infliximab or adalimumab may be a new treatment option for patients with severe refractory lymphocytic enterocolitis not responding to corticosteroids.
摘要
背景与目的
淋巴细胞性小肠结肠炎是一种吸收不良综合征，其特征为严重的小肠绒毛异常和隐窝增生，以及整个胃肠道内淋巴细胞密集浸润。
方法
我们报告了 2 例对常规医学治疗无效的淋巴细胞性小肠结肠炎患者，他们接受了肿瘤坏死因子拮抗剂治疗。
结果
这 2 例患者腹泻症状和肠道组织学异常均有临床改善。
结论
对于那些对皮质类固醇治疗无反应的严重难治性淋巴细胞性小肠结肠炎患者，肿瘤坏死因子-α拮抗剂（如英夫利昔单抗或阿达木单抗）可能是一种新的治疗选择。
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