肿瘤微环境中的癌症相关成纤维细胞（CAFs）。
Cancer associated fibroblasts (CAFs) in tumor microenvironment.
机构信息
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, School of Medicine, 751 N Rutledge St. PO Box 19626, Springfield, IL 627794-9626, USA.
出版信息
Front Biosci (Landmark Ed). 2010 Jan 1;15(1):166-79. doi: 10.2741/3613.
Abstract
Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor microenvironment which promotes the growth and invasion of cancer cells by various mechanisms. CAFs demonstrate a high degree of heterogeneity due to their various origins; however, many distinct morphological features and physiological functions of CAFs have been identified. It is becoming clear that the crosstalk between the cancer cells and the CAFs plays a key role in the progression of cancer, and understanding this mutual relationship would eventually enable us to treat cancer patients by targeting CAFs. In this review, we will discuss the latest findings on the role of CAFs in tumorigenesis and metastasis as well as potential therapeutic implication of CAFs.
摘要
癌症相关成纤维细胞（CAFs）是肿瘤微环境中最关键的组成部分之一，通过多种机制促进癌细胞的生长和侵袭。CAFs 因其起源不同而具有高度异质性，但已经确定了许多不同的形态特征和生理功能。越来越明显的是，癌细胞和 CAFs 之间的串扰在癌症的进展中起着关键作用，了解这种相互关系最终将使我们能够通过靶向 CAFs 来治疗癌症患者。在这篇综述中，我们将讨论 CAFs 在肿瘤发生和转移中的作用的最新发现以及 CAFs 的潜在治疗意义。
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