Lunina N A, Safina D R, Kostrov S V
National Research Center "Kurchatov Institute", Moscow, 123182 Russia.
Mol Biol (Mosk). 2023 Sep-Oct;57(5):739-770.
Cancer-associated fibroblasts (CAFs) often form a major component of the tumor microenvironment (TMA), providing conditions for cancer cells to thrive. CAFs may contribute to tumor growth, invasion, metastasis, and resistance to therapy. However, clinical trials of treatment strategies targeting CAFs have largely failed. Moreover, there is evidence that CAFs are capable of inhibiting tumor development. The review considers the current data on the functional heterogeneity of CAFs and their bimodality in tumor development and progression. Understanding the tumor-promoting and tumor-inhibiting activities of CAFs can help to develop new diagnostic and therapeutic approaches.
癌症相关成纤维细胞（CAFs）通常构成肿瘤微环境（TMA）的主要成分，为癌细胞的生长提供条件。CAFs可能促进肿瘤生长、侵袭、转移及对治疗产生抗性。然而，针对CAFs的治疗策略的临床试验大多失败了。此外，有证据表明CAFs能够抑制肿瘤发展。本综述探讨了关于CAFs功能异质性及其在肿瘤发生和进展中的双重作用的现有数据。了解CAFs的促肿瘤和抑肿瘤活性有助于开发新的诊断和治疗方法。
