Marinoni Emanuela, Frigiola Alessandro, Gazzolo Diego, Greco Papaleo, Vimercati Antonella, Moscarini Massimo, Abella Raul, Di Iorio Romolo
Centre for Scientific Research, San Pietro Hospital, Fatebenefratelli, Rome, Italy.
Front Biosci (Elite Ed). 2010 Jan 1;2(1):47-51. doi: 10.2741/e64.
We investigated the levels of S100 beta protein (S100B) in the serum of fetuses with neural tube defects (NTD), and their mother. Samples from 20 fetuses with NTD and 30 controls at the same gestational age, and their mothers, were studied. S100B protein levels were determined using Lia-mat Sangtec. kit. S100B concentrations were significantly higher in NTD fetuses (median 2.71 microg/L) than in control subjects (median 0.98 microg/L). Increased S100B levels were also found in mothers carrying fetuses with NTD compared to control and uncomplicated pregnancies. This study indicates that NTD is associated with increased serum concentration of S100B in fetuses and mothers. Moreover, it gives information on S100B levels in the fetal circulation in early-mid gestation.
我们研究了神经管缺陷（NTD）胎儿及其母亲血清中S100β蛋白（S100B）的水平。研究了20例患有NTD的胎儿及其30例相同孕周的对照胎儿，以及他们的母亲。使用Lia-mat Sangtec试剂盒测定S100B蛋白水平。NTD胎儿的S100B浓度（中位数2.71μg/L）显著高于对照对象（中位数0.98μg/L）。与对照和正常妊娠的母亲相比，怀有NTD胎儿的母亲体内S100B水平也有所升高。这项研究表明，NTD与胎儿和母亲血清中S100B浓度升高有关。此外，它还提供了妊娠早中期胎儿循环中S100B水平的信息。
