Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
Dis Markers. 2009;27(5):225-30. doi: 10.3233/DMA-2009-0667.
The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases.
In this study the possible relationship between Apo E alleles and PD patients was analyzed in 105 patients with PD and 107 healthy controls from a Mexican population.
Allele analysis in PD vs. controls was: epsilon2 in 6% and 2.3%, respectively; epsilon3 in 73% and 88.3%; and epsilon4} in 21% and 9.4%. The epsilon3 allele showed a protective risk effect with an Odds ratio (OR) of 0.36 (95%CI 0.20-0.61) and p < 0.05; contrary results were observed for the epsilon4 allele, which showed an increased risk for PD, with an OR of 2.57(95% CI 1.42-4.79) and p < 0.05. Upon multivariate analysis showed PD risk was evident in patients who were carriers of the genotype epsilon3/epsilon4; age group (fifty or more years) and had exposure to pesticides and solvents (p < 0.05).
The epsilon3/epsilon3}; epsilon3/epsilon4 genotypes of the Apo E, were positively associated with sporadic PD.
载脂蛋白（Apo E）-epsilon4 等位基因与神经退行性疾病（如帕金森病）的关联已在多项研究中进行了分析。这种关联已在神经退行性疾病患者的大脑中发现的淀粉样沉积物和神经纤维缠结中得到证实。
在这项研究中，分析了来自墨西哥人群的 105 例帕金森病患者和 107 名健康对照者中 Apo E 等位基因与帕金森病患者之间的可能关系。
PD 与对照组的等位基因分析分别为：epsilon2 分别为 6%和 2.3%；epsilon3 分别为 73%和 88.3%；epsilon4 分别为 21%和 9.4%。epsilon3 等位基因显示出保护性风险效应，优势比（OR）为 0.36（95%CI 0.20-0.61），p<0.05；而 epsilon4 等位基因则相反，表明帕金森病风险增加，OR 为 2.57（95%CI 1.42-4.79），p<0.05。多元分析显示，携带基因型 epsilon3/epsilon4 的患者、年龄组（五十岁或以上）以及接触农药和溶剂的患者具有明显的 PD 发病风险（p<0.05）。
Apo E 的 epsilon3/epsilon3；epsilon3/epsilon4 基因型与散发性帕金森病呈正相关。
