Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil.
Biomed Res Int. 2013;2013:641515. doi: 10.1155/2013/641515. Epub 2013 Sep 24.
The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. The studied polymorphism was analyzed by PCR/RFLP. The Fisher's exact test, chi-square, ANOVA, and t-test (P < 0.05) were applied. The APOE3/3 genotype was prevalent in PD patients and Controls (P = 0.713) followed by APOE3/4 (P = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (P < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the APOE3/3 versus APOE-/4 genotypes (P = 0.012). The APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only.
帕金森病（PD）的发病机制似乎涉及神经退行性变的遗传易感性。APOE 基因被认为是 PD 的危险因素。本研究旨在评估 APOE 多态性与 PD 的关系及其对血脂谱的影响。我们研究了 232 名 PD 患者（PD）和 169 名无该疾病的个体。通过 PCR/RFLP 分析研究的多态性。应用 Fisher 确切检验、卡方检验、方差分析和 t 检验（P <0.05）。APOE3/3 基因型在 PD 患者和对照组中更为常见（P = 0.713），其次是 APOE3/4（P = 0.772）。两组的血脂谱均在推荐范围内，与对照组相比，PD 患者的总胆固醇和 LDLc 水平升高，而甘油三酯水平降低（所有 P 值均<0.05）。与 APOE-/4 基因型相比，PD 患者的 APOE3/3 基因型与 HDLc 水平升高相关（P = 0.012）。APOE 多态性不能将 PD 患者与对照组区分开来，而单独的血脂谱或与 APOE 联合使用则可以。此外，仅在 PD 患者中发现 HDLc 水平升高与 APOE3 纯合子之间存在相关性。
