Sasaki F, Uchino J, Hata Y, Sato Y, Konno T, Okuno T, Ohira S, Taguchi K, Fuzisawa J, Oku T
1st Dept. of Surgery, School of Medicine, Hokkaido University, Sapporo, Japan.
Gan To Kagaku Ryoho. 1991 Mar;18(3):437-42.
Thirty patients with bone metastasis were treated with eel calcitonin (CT) to relieve severe pain from metastatic bone lesions. Patients were two males and twenty-eight females with a mean age of 52.8. CT was administered intramuscularly in twenty-seven patients and intravenously in three. CT was effective on 55.6% of patients to reduce severe bone pain but did not decrease the amount of analgesics in most patients. Serum Ca and P were not changed markedly. As side-effects, two patients complained of nausea and vomiting after administration of CT but they weren't severe. These results indicate that CT is quite useful drug for relief of severe bone pain from metastatic lesions in patients with breast or digestive tract carcinomas.
30例骨转移患者接受鳗鱼降钙素（CT）治疗，以缓解转移性骨病变引起的剧痛。患者中男性2例，女性28例，平均年龄52.8岁。27例患者采用肌肉注射CT，3例采用静脉注射。CT对55.6%的患者缓解重度骨痛有效，但大多数患者的镇痛药用量未减少。血清钙和磷无明显变化。作为副作用，2例患者在注射CT后出现恶心和呕吐，但症状不严重。这些结果表明，CT是缓解乳腺癌或消化道癌患者转移性病变所致重度骨痛的有效药物。
