一种通向具有结构多样性机会的单化学实体三嗪树枝状大分子的不同途径。
A divergent route towards single-chemical entity triazine dendrimers with opportunities for structural diversity.
作者信息
Crampton Hannah, Hollink Emily, Perez Lisa M, Simanek Eric E
机构信息
Department of Chemistry, Texas A&M University, College Station, TX 77845, USA.
出版信息
New J Chem. 2007 Jul 1;31(7):1283-1290. doi: 10.1039/b617875h.
Abstract
This manuscript describes the successful synthesis and characterization of five generations of dendrimers based on melamine. Early generations of these materials appear to be single chemical entities: upon purification, no detectable impurities are observed using NMR spectroscopy, mass spectrometry, and HPLC and GPC analysis. The analysis of larger generation materials precludes an unambiguous statement of purity. The synthetic route to these targets is divergent, relying on dichlorotriazine monomers that react with a polyamine dendrimer core of generation n to produce a poly(monochlorotriazine) dendrimer of generation n + 1. Subsequently, the poly(monochlorotriazine) is derivatized through nucleophilic aromatic substitution before additional nucleophilic amines are unmasked and the process iterated.
摘要
本手稿描述了基于三聚氰胺的五代树枝状大分子的成功合成与表征。这些材料的早期几代似乎是单一化学实体：纯化后，使用核磁共振光谱、质谱以及高效液相色谱和凝胶渗透色谱分析均未观察到可检测到的杂质。对更大代数材料的分析无法明确说明其纯度。这些目标产物的合成路线是发散型的，依赖于二氯三嗪单体，该单体与第n代的多胺树枝状大分子核心反应，生成第n + 1代的聚（一氯三嗪）树枝状大分子。随后，通过亲核芳香取代对聚（一氯三嗪）进行衍生化，然后再解封额外的亲核胺并重复该过程。
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