Ersoy Omer Faik, Kayaoğlu Hüseyin Ayhan, Celik Alper, Ozkan Namik, Lortlar Neşe, Omeroğlu Suna
Department of General Surgery, Gaziosmanpaşa University ,Faculty of Medicine, Tokat, Turkey.
Ulus Travma Acil Cerrahi Derg. 2009 Nov;15(6):535-40.
We aimed to compare conventional suture closure of arteriotomy with N-butyl-cyanoacrylate-assisted suture closure.
Forty Wistar rats were randomly divided into two groups. Standard arteriotomy was performed to the abdominal aorta through a midline incision. In the first group, arteriotomy was closed by 3 stitches with 45 degrees between each and in the second by two stitches with 0.1 ml (12-12.5 mg) cyanoacrylate. Amount of blood loss, operation time and severity of myointimal hyperplasia by immunohistochemistry on aorta segments were measured on postoperative days 7 and 30.
Mean anastomotic time was 13.5 +/- 1.64 in the first and 13.0 +/- 1.75 min in the second group (p = 0.356). Operation time was 23.45 +/- 3.63 in the control and 21.0 +/- 3.09 min in the second group (p = 0.027). Mean amount of bleeding was 473.75 +/- 260.5 in the first and 327.5 +/- 155.36 microl in the second group (p = 0.037). Intimal thickness on the 7th day was 80.62 +/- 7.92 in the first and 83.24 +/- 3.42 microm in the second group, and on the 30th day was 81.64 +/- 5.11 in the first and 88.77 +/- 11.03 microm in the second group. The early and late intimal thicknesses were similar (p = 0.35 and 0.87, respectively).
Reconstruction of arteriotomies with fewer sutures in combination with cyanoacrylate is a safe method associated with less blood loss and shorter operation time. It also does not lead to increased myointimal hyperplasia.
我们旨在比较动脉切开术的传统缝合闭合与氰基丙烯酸正丁酯辅助缝合闭合。
40只Wistar大鼠随机分为两组。通过中线切口对腹主动脉进行标准动脉切开术。第一组，动脉切开术用3针缝合，每针之间呈45度角；第二组用2针缝合，并使用0.1毫升（12 - 12.5毫克）氰基丙烯酸酯。在术后第7天和第30天测量失血量、手术时间以及通过主动脉段免疫组织化学检测的肌内膜增生严重程度。
第一组平均吻合时间为13.5 ± 1.64分钟，第二组为13.0 ± 1.75分钟（p = 0.356）。对照组手术时间为23.45 ± 3.63分钟，第二组为21.0 ± 3.09分钟（p = 0.027）。第一组平均出血量为473.75 ± 260.5微升，第二组为327.5 ± 155.36微升（p = 0.037）。第7天第一组内膜厚度为80.62 ± 7.92微米，第二组为83.24 ± 3.42微米；第30天第一组为81.64 ± 5.11微米，第二组为88.77 ± 11.03微米。早期和晚期内膜厚度相似（分别为p = 0.35和0.87）。
用较少缝线结合氰基丙烯酸酯重建动脉切开术是一种安全的方法，具有失血量少和手术时间短的特点。它也不会导致肌内膜增生增加。
