Zhao M, Jiang Y, Abrahams I W
Department of Ophthalmology, Second Affiliated Hospital, Human Medical University, Peoples Republic of China.
Arch Ophthalmol. 1991 Mar;109(3):368-70. doi: 10.1001/archopht.1991.01080030070041.
Vogt-Koyanagi-Harada syndrome, or the uveomeningitis syndrome, is one of the most commonly identified types of endogenous uveitis diagnosed in China. Because its incidence is higher in Orientals than in whites, immunogenetic background [corrected] may be an important factor in its incidence. We performed HLA-A, -B, and -DR typing on 25 patients with Vogt-Koyanagi-Harada syndrome and on 65 healthy control subjects from the Han Chinese population. The results showed that HLA-DR4 and -Dw53 were closely associated with Vogt-Koyanagi-Harada syndrome (P less than .001 [relative risk = 16.0] and P less than .001 [relative risk = 34.2], respectively). This association is similar to that reported in patients with Vogt-Koyanagi-Harada syndrome in Japan, suggesting that DR4 and DRw53 may play important roles in the development of Vogt-Koyanagi-Harada syndrome in Oriental populations.
伏格特-小柳-原田综合征，即葡萄膜脑膜炎综合征，是中国最常见的内源性葡萄膜炎类型之一。由于其在东方人中的发病率高于白种人，免疫遗传背景[校正后]可能是其发病率的一个重要因素。我们对25例伏格特-小柳-原田综合征患者和65名来自汉族人群的健康对照者进行了HLA - A、- B和-DR分型。结果显示，HLA - DR4和-Dw53与伏格特-小柳-原田综合征密切相关（P均小于0.001[相对风险分别为16.0和34.2]）。这种关联与日本伏格特-小柳-原田综合征患者的报道相似，提示DR4和DRw53可能在东方人群伏格特-小柳-原田综合征的发病中起重要作用。
