Rutzen A R, Ortega-Larrocea G, Schwab I R, Rao N A
Doheny Eye Institute, Los Angeles, CA 90033.
Am J Ophthalmol. 1995 Feb;119(2):239-40. doi: 10.1016/s0002-9394(14)73884-x.
PURPOSE/METHODS: We examined monozygotic twins of Vietnamese ancestry in whom the Vogt-Koyanagi-Harada syndrome developed.
RESULTS/CONCLUSIONS: Both patients demonstrated typical clinical findings of the Vogt-Koyanagi-Harada syndrome, and HLA typing disclosed HLA-DR4, an antigen that is present in a disproportionate number of patients with the Vogt-Koyanagi-Harada syndrome. Although familial cases of the Vogt-Koyanagi-Harada syndrome are rare, associations with HLA antigens may indicate that genetic factors play a role in this disease.
目的/方法：我们研究了患有Vogt-小柳-原田综合征的越南裔同卵双胞胎。
结果/结论：两名患者均表现出Vogt-小柳-原田综合征的典型临床症状，且HLA分型显示为HLA-DR4，该抗原在Vogt-小柳-原田综合征患者中出现的比例过高。虽然Vogt-小柳-原田综合征的家族病例很少见，但与HLA抗原的关联可能表明遗传因素在这种疾病中起作用。
