钯催化的芳基溴化物通过 C-H 功能化的分子内酰化反应：苯并环丁烯酮的高效合成。
Pd-catalyzed intramolecular acylation of aryl bromides via C-H functionalization: a highly efficient synthesis of benzocyclobutenones.
机构信息
Institute of Chemical Research of Catalonia (ICIQ), 43007 Tarragona, Spain.
出版信息
J Am Chem Soc. 2010 Jan 20;132(2):466-7. doi: 10.1021/ja909811t.
PMID:20038097
Abstract
A new catalyst system for the intramolecular acylation of aldehydes with aryl bromides via C-H functionalization is described. The transformation is distinguished by a remarkable functional group tolerance and hence allows for the synthesis of a wide variety of highly functionalized benzocyclobutenones with a diverse set of substitution patterns from simple and easily accessible precursors.
摘要
本文描述了一种新的催化剂体系，用于通过 C-H 功能化实现醛与芳基溴化物的分子内酰化反应。该转化具有显著的官能团容忍性，因此可以从简单易得的前体合成具有各种取代模式的多种高度官能化的苯并环丁烯酮。
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