From the Maternal and Child Care Union, Tbilisi, Georgia.
Infect Control Hosp Epidemiol. 2010 Feb;31(2):158-64. doi: 10.1086/649795.
While the Republic of Georgia has a high prevalence of hepatitis B virus (HBV) infection (3.4% of blood donors tested positive for HBV surface antigen [HBsAg]), relatively few healthcare workers (HCWs) are thought to be immunized.
To measure rates of HBV vaccination coverage and identify predictors of vaccine acceptance among HCWs.
Cross-sectional survey.
A study was conducted among full-time physicians and nurses at 2 large hospitals. Self-administered questionnaires included questions about demographic characteristics, HBV vaccine status, willingness to recommend vaccination to other HCWs, and barriers to vaccination. Laboratory tests were conducted for identification of HBsAg and antibody to hepatitis B core antigen.
A total of 297 (91%) of 325 randomly selected HCWs provided information for the study (124 physicians and 173 nurses). The rate of HBV vaccination coverage was 12%, and 54% of respondents indicated that they would recommend vaccination to other HCWs. Perception of vaccine safety was identified as the most important predictor for acceptance (prevalence ratio [PR], 3.3 [95% confidence ratio {CI}, 1.2-8.9]) and for willingness to recommend HBV vaccination to other HCWs (PR, 5.5 [95% CI, 3.1-9.4]). Vaccinated HCWs were more likely to recommend vaccination to other healthcare personnel (PR, 1.7 [95% CI, 1.5-2.1]), as were those younger than 40 years of age (PR, 6.0 [95% CI, 2.8-12.6]). Multivariate analyses identified 2 additional factors associated with vaccine acceptance and willingness to recommend vaccination: the hospital at which the HCW was employed and the perception of risk of infection for HCWs.
Georgia plans a major HBV vaccination campaign for HCWs in 2009. The campaign's success will depend on addressing vaccine safety concerns identified in this study and educating HCWs about risk factors for infection and benefits of immunization.
格鲁吉亚共和国乙型肝炎病毒（HBV）感染率较高（3.4%的献血者 HBV 表面抗原[HBsAg]阳性），但据认为，只有少数医护人员（HCW）接种了疫苗。
测量 HBV 疫苗接种率，并确定 HCW 对疫苗接种的接受率的预测因素。
横断面调查。
在两家大医院对全职医生和护士进行了一项研究。自填式问卷包括关于人口统计学特征、HBV 疫苗状况、向其他 HCW 推荐疫苗接种的意愿以及疫苗接种障碍的问题。进行实验室检测以确定 HBsAg 和乙型肝炎核心抗原抗体。
在随机选择的 325 名 HCW 中，共有 297 名（91%）提供了研究资料（124 名医生和 173 名护士）。HBV 疫苗接种率为 12%，54%的受访者表示他们将向其他 HCW 推荐疫苗接种。疫苗安全性的认知被确定为接受疫苗接种的最重要预测因素（优势比[PR]，3.3[95%置信区间{CI}，1.2-8.9]）和向其他 HCW 推荐 HBV 疫苗接种的意愿（PR，5.5[95%CI，3.1-9.4]）。接种疫苗的 HCW 更有可能向其他医疗保健人员推荐疫苗接种（PR，1.7[95%CI，1.5-2.1]），年龄小于 40 岁的 HCW 也是如此（PR，6.0[95%CI，2.8-12.6]）。多变量分析确定了与疫苗接种接受率和推荐疫苗接种意愿相关的另外两个因素：HCW 工作的医院和 HCW 感染风险的认知。
格鲁吉亚计划在 2009 年为 HCW 开展大规模 HBV 疫苗接种运动。该运动的成功将取决于解决本研究中确定的疫苗安全问题，并对 HCW 进行有关感染风险因素和免疫益处的教育。
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