关节炎中的体内白细胞迁移。

In vivo leukocyte migration in arthritis.

作者信息

Jones A K, al-Janabi M A, Solanki K, Sobnack R, Greenwood A, Doyle D V, Britton K E, Huskisson E C

机构信息

Department of Nuclear Medicine, St. Bartholomew's Hospital Medical School, London, UK.

出版信息

Arthritis Rheum. 1991 Mar;34(3):270-5. doi: 10.1002/art.1780340304.

DOI:10.1002/art.1780340304

PMID:2003853

Abstract

We quantitated in vivo migration of neutrophils into the knees of patients with rheumatoid arthritis (RA) and osteoarthritis, using 99mtechnetium-hexamethyl-propylene-amineoxime-labeled leukocytes and gamma scintigraphy. Significant neutrophil migration occurred in patients with RA irrespective of disease duration, and it was reduced by 60% following intraarticular steroid injection. The reduction in neutrophil migration correlated with reduction in pain. Leukocyte migration into osteoarthritic joints was also demonstrated, although it was much less than that seen in rheumatoid joints. No significant leukocyte migration into the joints of patients without arthritis was demonstrated. This technique appears to provide a sensitive method for quantitatively assessing the neutrophil component of inflammation in individual joints of patients with arthritis.

摘要

我们使用99m锝-六甲基丙烯胺肟标记的白细胞和γ闪烁显像技术，对类风湿关节炎（RA）和骨关节炎患者膝关节内中性粒细胞的体内迁移进行了定量研究。无论病程长短，RA患者均出现显著的中性粒细胞迁移，关节内注射类固醇后迁移减少了60%。中性粒细胞迁移的减少与疼痛减轻相关。骨关节炎关节中也证实有白细胞迁移，尽管比类风湿关节中的迁移少得多。未发现无关节炎患者的关节中有明显的白细胞迁移。这项技术似乎为定量评估关节炎患者单个关节炎症中的中性粒细胞成分提供了一种灵敏的方法。