骨关节炎中的放射性白细胞闪烁扫描术。是否存在炎症成分？

Radioleucoscintigraphy in osteoarthritis. Is there an inflammatory component?

作者信息

al-Janabi M A, Solanki K, Critchley M, Smith M L, Britton K E, Huskisson E C

机构信息

Department of Nuclear Medicine, Royal Liverpool University Hospital, UK.

出版信息

Nucl Med Commun. 1992 Oct;13(10):706-12.

PMID:1491834

Abstract

The possible contribution of an inflammatory component in osteoarthritis was investigated. There was no correlation between the percentage uptakes of 99Tcm-hexamethylpropyleneamine oxime (HMPAO)-labelled white blood cells and 99Tcm-methylene diphosphonate (MDP) and between the former and pain scores. A significant correlation was found between the percentage uptake of 99Tcm-MDP and pain scores (0.002 > P > 0.01). In osteoarthritis, 99Tcm-HMPAO-labelled white cell imaging may or may not show a positive localization in the synovial membrane. Positive white cell localization appears to be limited to the area that corresponds to the radiological evidence of the condition and the positive uptake of the skeletal imaging agent.

摘要

研究了炎症成分在骨关节炎中的可能作用。99锝-六甲基丙烯胺肟（HMPAO）标记的白细胞摄取百分比与99锝-亚甲基二膦酸盐（MDP）摄取百分比之间以及前者与疼痛评分之间均无相关性。发现99锝-MDP摄取百分比与疼痛评分之间存在显著相关性（0.002＞P＞0.01）。在骨关节炎中，99锝-HMPAO标记的白细胞显像在滑膜中可能显示阳性定位，也可能不显示。白细胞阳性定位似乎仅限于与病情的放射学证据及骨骼显像剂阳性摄取相对应的区域。