Clow D W, Hammer R P
Department of Anatomy and Reproductive Biology, University of Hawaii School of Medicine, Honolulu 96822.
Neuropsychopharmacology. 1991 Jan;4(1):71-5.
2-[14C]deoxyglucose autoradiography was used to determine local cerebral glucose utilization (lCGU) in rats following chronic cocaine treatment and subsequent abstinence. lCGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced lCGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, lCGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.
采用2-[14C]脱氧葡萄糖放射自显影术来测定慢性给予可卡因及随后戒断的大鼠的局部脑葡萄糖利用率（lCGU）。对每日注射可卡因14天（10毫克/千克），随后用生理盐水或溴隐亭（10毫克/千克）处理3天的动物，检测其43个离散脑区的lCGU。慢性处理后的可卡因戒断显著降低了包括中脑皮质边缘结构（如腹侧被盖区、内侧前额叶皮质和伏隔核（NAc））在内的多个区域的lCGU。然而，在NAc内，只有吻侧极显示出显著降低。相比之下，当溴隐亭处理伴随戒断时，中脑皮质边缘和大多数其他区域的lCGU不再降低，这意味着在慢性可卡因处理后的早期戒断期间，溴隐亭处理可增强代谢恢复。这些数据表明，在慢性处理后的可卡因戒断期间，关键脑区的脑代谢降低，并且这种改变可以通过使用直接作用的多巴胺激动剂（如溴隐亭）进行治疗来预防。
